how bacteria adhere to cells: basis for the development of a new class of antibiotics
Adhesion of Bartonella henselae to human cells. B. henselae (strain Marseille) bacteria (light blue) in an early stage infection process (30 min) to human HeLa-229 cells (red). Adhesion to host cells is mediated by specific interactions between B. henselae surface proteins and components of the host extracellular matrix including molecules such as fibronectin or collagen. Scale bar: 8 μm. Credit: Microbiology Spectrum (2022). DOI: 10.1128/spectrum.00598-22

Researchers from University Hospital Frankfurt and Goethe University Frankfurt have unraveled how bacteria adhere to host cells and thus taken the first step towards developing a new class of antibiotics.

The adhesion of bacteria to host cells is always the first, decisive step in the development of infectious diseases. The purpose of this adhesion by infectious pathogens is to colonize the host organism (e.g., the human body) then trigger an infection, which can end fatally in the worst case. A precise understanding of the bacteria’s adhesion to host cells is key to finding therapeutic alternatives that block this critical interaction in the earliest possible stage of an infection.

Critical interaction with the human protein fibronectin

In collaboration with other researchers, scientists from University Hospital Frankfurt and Goethe University Frankfurt have now explained the exact bacterial adhesion mechanism using the human-pathogenic bacterium Bartonella henselae. This pathogen causes “cat-scratch disease,” a disease transmitted from animals to humans. In an international collaborative project led by the Frankfurt research group headed by Professor Volkhard Kempf, the bacterial adhesion mechanism was deciphered with the help of a combination of in-vitro adhesion tests and high-throughput proteomics. Proteomics is the study of all the proteins present in a cell or a complex organism.

In their study published in Microbiology Spectrum, the scientists shed light on a key mechanism: the bacterial adhesion to the host cells can be traced back to the interaction of a certain class of adhesins—called “trimeric autotransporter adhesins”—with fibronectin, a protein often found in human tissue. Adhesins are components on the surface of bacteria that enable the pathogen to adhere to the host’s biological structures. Homologues of the adhesin identified here as critical are also present in many other human-pathogenic bacteria, such as the multi-resistant Acinetobacter baumannii, which the World Health Organization (WHO) has classified as the top priority for research into new antibiotics.

State-of-the-art protein analytics were used to visualize the exact points of interaction between the proteins. In addition, it was possible to show that experimental blocking of these processes almost entirely prevents bacterial adhesion. Therapeutic approaches that aim to prevent bacterial adhesion in this way could represent a promising treatment alternative as a new class of antibiotics (known as “anti-ligands”) in the constantly growing domain of multi-resistant bacteria. More information: Diana J. Vaca et al, Interaction of Bartonella henselae with Fibronectin Represents the Molecular Basis for Adhesion to Host Cells, Microbiology Spectrum (2022). DOI: 10.1128/spectrum.00598-22 Provided by Goethe University Frankfurt am Main Citation: How bacteria adhere to cells: Basis for the development of a new class of antibiotics (2022, June 30) retrieved 30 June 2022 from https://phys.org/news/2022-06-bacteria-adhere-cells-basis-class.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

TECH'S NEWS RELATED

Ultrathin dental camera inspired by insect-eye structure

A fully packaged ultrathin dental camera and multifunctional dental images. Credit: The Authors, doi 10.1117/1.JOM.2.3.031202. Conventional dental photography technology has had a limitation in using inconvenient tools such as mirrors and cheek retractors. Dentists require basic teeth images from various angles, such as right/left buccal and maxillary/mandibular occlusal, for ...

View more: Ultrathin dental camera inspired by insect-eye structure

Top 5 Smart Garage Door Openers

1. Chamberlain MyQ Smart Garage Door Opener 2. Garadget Smart Garage Door Controller 3. Nexx Smart WiFi Door Opener 4. GoControl Smart Garage Door Controller 5. Meross Smart Garage Door Opener Benefits Of A Smart Door Opener For The Garage Photo : Brandi Alexandra on Unsplash Few will deny ...

View more: Top 5 Smart Garage Door Openers

Scientists are discovering ways to eliminate PFAS, but this growing global health problem isn't going away soon

Credit: Pixabay/CC0 Public Domain PFAS chemicals seemed like a good idea at first. As Teflon, they made pots easier to clean starting in the 1940s. They made jackets waterproof and carpets stain-resistant. Food wrappers, firefighting foam, even makeup seemed better with perfluoroalkyl and polyfluoroalkyl substances. Then tests started detecting ...

View more: Scientists are discovering ways to eliminate PFAS, but this growing global health problem isn't going away soon

Forecasting the future to help protect monarch butterflies 

Credit: CC0 Public Domain The outlook for monarch butterflies isn’t great right now. In fact, the International Union for the Conservation of Nature, or IUCN, just added North America’s monarchs to its list of endangered species. With news like this, it can be easy to overlook the reasons to ...

View more: Forecasting the future to help protect monarch butterflies 

Grandoreiro banking malware targets manufacturers in Spain, Mexico

Starts with an email Grandoreiro features The notorious ‘Grandoreiro’ banking trojan was spotted in recent attacks targeting employees of a chemicals manufacturer in Spain and workers of automotive and machinery makers in Mexico. The malware has been active in the wild since at least 2017 and remains one of ...

View more: Grandoreiro banking malware targets manufacturers in Spain, Mexico

YouTube will watermark Shorts videos

The YouTube Shorts platform will begin adding watermarks to uploaded videos. Such a measure will help combat reposts of the same content on different sites. Following the explosion of TikTok, other internet companies have realized that short videos are extremely popular among the younger generation and have come up with ...

View more: YouTube will watermark Shorts videos

iQOO Neo 7 coming with Dimensity 9000+ and 120W charging

Vivo is preparing a bunch of new smartphones for the second half of 2022. Among them, the company has a new Vivo X Fold S that is likely to bring the Snapdragon 8+ Gen 1 SoC and the iQOO Neo 7. The latter will be the company’s next entry in ...

View more: iQOO Neo 7 coming with Dimensity 9000+ and 120W charging

The Company Bought 750 Acres In Costa Rica For $30 Million To Build A Sustainable Blockchain Project

(Photo : Alóki) Alóki tackles a new frontier by reconnecting people to nature through blockchain technology. Its play-to-own metaverse will provide entertainment and amusement but also enable users to do good for the planet and help build a sustainable future for society at large. The efforts by Alóki focus ...

View more: The Company Bought 750 Acres In Costa Rica For $30 Million To Build A Sustainable Blockchain Project

Social network BeReal shares unfiltered and unedited moments from our lives—will it last?

New tool checks if in-app mobile browsers inject risky code on sites

Xiaomi’s revenue fell by 20% due to Chinese lockdowns

New Lindo Dual Camera Video Doorbell – end the porch piracy

NASA's moon-landing astronauts will explore 1 of these regions

Scientists take a deep dive into how sharks use the ocean

60 million years of climate change drove the evolution and diversity of reptiles

A third straight La Niña is likely—here's how you and your family can prepare

Stop dissing pessimism—it's part of being human

Built-in TikTok app browser caught adding tracking code to pages

Every She-Hulk episode will have a credits scene

Optimum Internet Review: Not the Best, Not the Worst Internet Service

OTHER TECH NEWS